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Diphenhydramine (Generic Benadryl)



What is Diphenhydramine?

Diphenhydramine is an antihistamine that is commonly used in both humans and pets. It is used in the treatment of many symptoms, including allergies and car sickness.


Cats and Dogs


  • Used for hyperexcitability
  • Effectively relieves allergy symptoms and itching
  • Treats motion sickness or travel anxiety
  • Relieves coughing


This medication should not be used in pregnant or nursing animals. Do not use the diphenhydramine available in combination with sinus or cold medicines in your pet. Do not use this medication in animals that are allergic to it or other antihistamines. Do not use in animals with glaucoma, prostate disease, urinary obstruction, and high blood pressure. Use with caution when given with other CNS (central nervous system)-depressant drugs such as tranquilizers or barbiturates. Always tell your veterinarian what other medications your pet is taking.

Brand Name


Generic Name

Diphenhydramine (dye-fen-hy¿-dra-meen)



Side effects:

Side effects of diphenhydramine include drowsiness, dry mouth and urinary retention. Rarely, vomiting and diarrhea can occur.

How should I store this medication:

Keep this medication in the container it came in, tightly closed. Store this medication at room temperature, away from excess heat, light, and moisture. Do not store in the bathroom. Throw away any medication that is outdated or no longer needed. Keep medication away from children and pets.


Oral diphenhydramine is not FDA-approved for use in veterinary medicine; however, it is a commonly accepted practice to use this medication in dogs and cats. The slow release capsule should not be mixed or dissolved in food.


Dogs/Cats:All WeightsGive 0.5 - 2mg per lb of pets body weight every 8 -12 hours

Active Ingredients (per Minitab):

ProductActive Ingredients
Diphenhydramine HCl 25 mg MinitabDiphenhydramine     25 mg

Other Ingredients (per capsule):
Corn starch, D&C red #27, Dicalcium Phosphate, Magnesium Stearate, Microcrystalline Cellulose, Polyethylene Glycol, Polyvinyl Alcohol, Silicon Dioxide, Stearic Acid, Talc, Titanium Dioxide.

Active Ingredients (per capsule):

ProductActive Ingredients
Diphenhydramine 50 mg CapsulesDiphenhydramine Hydrochloride     50 mg

Other Ingredients (per capsule):
Colloidal Silicon Dioxide, Croscamellose Sodium, D&C Red #28, FD&C Blue #1, FD&C Red #3, FD&C Red #40, Gelatin, Lactose, Magnesium Stearate. May also contain Polysorbate 80 and iron oxide.

  • Used for hyperexcitability
  • Effectively relieves allergy symptoms and itching
  • Treats motion sickness or travel anxiety
  • Relieves coughing


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